Rituximab-Based Treatment, HCV Replication, and Hepatic Flares

Rituximab, a chimeric mouse-human monoclonal antibody directed to the CD20 antigen expressed on pre-B lymphocytes and mature lymphocytes, causes a profound B-cell depletion.Due to its peculiar characteristics, this drug has been used to treat oncohaematological diseases, B cell-related autoimmune diseases, rheumatoid arthritis, and, more recently,

read more

Novel 1, 2, 3-triazolic compounds derived from cytosine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking studies

The development of novel antimicrobial drugs is crucial due to the increasing problem of antibiotic resistance.A new series of 1,4-disubstituted-1,2,3-triazole derivatives containing a cytosine moiety (3a, 3b, 3c and 3d) were synthesized using 1,3-dipolar equi-jec 6 cycloaddition in a mixture of ethanol and water under Cu(I)-catalyzed with N-alkyl:

read more



Depression in the South African workplace

Depression is a common psychiatric disorder and can be costly, having a significant impact on the individual and employers.The South African Depression and Anxiety Group (SADAG) in partnership with HEXOR, with the support of Lundbeck, undertook research into depression in the workplace, because South African information is not available on this top

read more